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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DDX3X
All Species:
16.97
Human Site:
S591
Identified Species:
26.67
UniProt:
O00571
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.36
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00571
NP_001347.3
662
73243
S591
S
R
G
R
S
K
S
S
R
F
S
G
G
F
G
Chimpanzee
Pan troglodytes
Q6GVM6
660
73172
N589
S
R
G
R
S
K
S
N
R
F
S
G
G
F
G
Rhesus Macaque
Macaca mulatta
XP_001095294
910
100218
S840
S
S
R
G
R
S
K
S
S
R
F
S
G
G
F
Dog
Lupus familis
XP_861268
662
73195
S591
S
R
G
R
S
K
S
S
R
F
S
G
G
F
G
Cat
Felis silvestris
Mouse
Mus musculus
Q62167
662
73083
S591
S
R
G
R
S
K
S
S
R
F
S
G
G
F
G
Rat
Rattus norvegicus
NP_001102328
659
72976
S588
G
S
R
G
R
S
K
S
R
F
S
G
G
F
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512924
651
71975
S577
S
R
G
R
S
K
S
S
R
F
S
G
G
F
G
Chicken
Gallus gallus
NP_001025971
651
72031
R580
K
G
G
G
S
R
G
R
S
K
S
R
F
T
G
Frog
Xenopus laevis
P24346
697
77284
R626
Q
H
H
K
S
S
S
R
G
R
S
K
S
R
F
Zebra Danio
Brachydanio rerio
NP_571016
688
75828
R617
H
Q
H
K
S
S
S
R
G
R
S
K
R
F
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VHP0
798
85063
G710
R
A
G
R
G
G
G
G
R
Y
G
G
G
F
G
Honey Bee
Apis mellifera
XP_391829
701
78642
A631
S
G
G
G
S
R
R
A
G
S
T
K
G
R
F
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9M2F9
646
69224
R555
K
N
R
R
S
G
G
R
F
G
G
R
D
F
R
Baker's Yeast
Sacchar. cerevisiae
P24784
617
67899
Q547
F
L
S
D
L
S
R
Q
N
S
R
G
G
R
T
Red Bread Mold
Neurospora crassa
Q9P6U9
688
72037
R603
R
G
G
R
G
G
G
R
G
G
G
R
G
R
T
Conservation
Percent
Protein Identity:
100
91.3
70.1
99.8
N.A.
98.6
95.3
N.A.
95.9
91.2
82.2
76.3
N.A.
51.7
58
N.A.
N.A.
Protein Similarity:
100
95.3
70.3
99.8
N.A.
99
97.1
N.A.
97.2
94.7
88
83.8
N.A.
63.4
70
N.A.
N.A.
P-Site Identity:
100
93.3
20
100
N.A.
100
53.3
N.A.
100
26.6
20
26.6
N.A.
46.6
26.6
N.A.
N.A.
P-Site Similarity:
100
100
20
100
N.A.
100
53.3
N.A.
100
33.3
26.6
40
N.A.
53.3
46.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
49.5
49.4
52
Protein Similarity:
N.A.
N.A.
N.A.
64.6
65.2
64.8
P-Site Identity:
N.A.
N.A.
N.A.
20
13.3
20
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
0
0
7
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
0
0
0
0
0
0
0
0
7
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
7
0
0
0
0
0
0
0
7
40
7
0
7
60
20
% F
% Gly:
7
20
60
27
14
20
27
7
27
14
20
54
74
7
54
% G
% His:
7
7
14
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
14
0
0
14
0
34
14
0
0
7
0
20
0
0
0
% K
% Leu:
0
7
0
0
7
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
0
0
0
0
0
7
7
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
7
7
0
0
0
0
0
7
0
0
0
0
0
0
0
% Q
% Arg:
14
34
20
54
14
14
14
34
47
20
7
20
7
27
7
% R
% Ser:
47
14
7
0
67
34
47
40
14
14
60
7
7
0
7
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
7
0
0
7
14
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _